Matrix metalloproteinase-9 contributes to intestinal tumourigenesis in the adenomatous polyposis coli multiple intestinal neoplasia mouse
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چکیده
منابع مشابه
Adenomatous polyposis coli regulates Drosophila intestinal stem cell proliferation.
Adult stem cells define a cellular reserve with the unique capacity to replenish differentiated cells of a tissue throughout an organism's lifetime. Previous analysis has demonstrated that the adult Drosophila midgut is maintained by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli (Apc), a tumor suppressor gene conserved in ...
متن کاملThe threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controller of the Wnt/beta-catenin pathway. To investigate the dose-dependent effects of APC protein in suppressing intestinal tumorigenesis, we constructed mutant mice carrying hypomorphic Apc alleles Apc(neoR) and Apc(neoF) whose expression levels were reduced to ...
متن کاملMatrix metalloproteinase-9 contributes to choroidal neovascularization.
Age-related macular degeneration (AMD) is the primary cause of irreversible photoreceptors loss in adult patients and current therapies are limited. Increased levels of matrix metalloproteinases (MMPs) have been documented in neovascularization of severe ocular pathologies such as AMD and proliferative diabetic retinopathy. We report here that MMP-9 (gelatinase B) expression is induced and temp...
متن کامل[Intestinal and extraintestinal manifestations in familial adenomatous polyposis].
Familijarna adenomatozna polipoza (FAP) je autozomno dominantni polipozni sindrom, odgovoran za pojavu oko 1% svih kolorektalnih karcinoma (CRC) . Ovaj sindrom se ispoljava kod 1/5 000 do 1/17 000 živorođene dece 2, 3 sa stopom penetracije od preko 90% . Zahvata podjednako oba pola i sve geografske lokalitete . Obolele osobe razvijaju 100−5 000 adenoma (prosečan broj adenoma > 1 000) tubularne ...
متن کاملMatrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.
Recent studies have implicated a pathogenic role for matrix metalloproteinases 9 (MMP-9) in inflammatory bowel disease. Although loss of epithelial barrier function has been shown to be a key pathogenic factor for the development of intestinal inflammation, the role of MMP-9 in intestinal barrier function remains unclear. The aim of this study was to investigate the role of MMP-9 in intestinal ...
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ژورنال
عنوان ژورنال: International Journal of Experimental Pathology
سال: 2008
ISSN: 0959-9673
DOI: 10.1111/j.1365-2613.2008.00621.x